Addendum – Cardiovascular Safety of CGRP Antagonists- Pharmacist


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The April 2019 issue of The Rx Consultant (New Drugs 2018) included a section that highlighted calcitonin gene-related peptide (CGRP) antagonists, a new class of drugs developed for migraine prevention (erenumab [AimovigTM], fremanezumab [AjovyTM], galcanezumab, [EmgalityTM]). We would like to provide some additional safety information. CGRP is a vasodilator that may help protect organs against ischemic injury; thus, CGRP antagonists might, theoretically, increase the risk of cardiovascular (CV) events (eg, heart attack, stroke) in people with pre-existing CV compromise.< Migraine itself is a risk factor for stroke and heart attack. Currently, there is no clinical evidence that CGRP antagonists increase CV risk. However, the placebo-controlled trials were short-term (3-6 months) and excluded patients with high CV risk. In an ongoing open-label extension study of erenumab, interim 3-year analysis found lower-than-expected CV event rates; however, the expected rates were derived from a large claims database9 (likely including higher-risk migraine patients)...


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Course Information

Target Audience

Pharm/Nurse Drug Therapy

James Chan
PharmD, PhD
Knowledge Level

General Overview

This activity will apply to a broad range of learning needs/pharmacy settings. It may include common disease state/therapy overivews and/or general pharmacy needs such as medication errors, immunizations, or law topics.

Learning Objectives

Course Accreditation

  • Activity Type:
  • CE Broker
  • Universal Activity Number:
    Pharmacist : There
PharmCon is accredited by the Accreditation Council for Pharmacy Education as a provider of continuing pharmacy education.

PharmCon, Inc. is an approved course provider for continuing education for nurses by the Florida Board of Nursing. PharmCon is also recognized by the California Board of Nursing as a provider of nursing programs.

In order to obtain a Statement of Credit, attendees must answer poll questions where presented and complete a program evaluation. Attendees may immediately print their Statement of Credit or leave them stored on the website.

Technology Requirements

  • Hardware Requirements
    Standard Windows/Mac System
    iPad or iPhone
    Minimum screen resolution: 1024x768
    Speakers or headphones
  • Software Requirements
    Standard Windows/Mac System
    iPad or iPhone
    Minimum screen resolution: 1024x768
    Speakers or headphones
  • Network Requirements
    Broadband Internet Connection:
    T1, Hi-speed DSL or Cable
    4G cellular connection
Computer sharing is NOT permitted due to accreditation guidelines on activity monitoring. Credit is earned by one user per device.