Cytochrome P450 System Part I: Background, Mechanism of Interactions, and Main CYP Isoforms Involved in Drug Metabolism
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As rates of polypharmacy rise and medication regimens become more complex, the risk of potential CYP-mediated drug-drug interactions is continuously growing. Additionally, the understanding of polymorphism and epigenetics is providing insight into how changes in CYP genes may be responsible for inter-individual variations in these interactions, disease susceptibility, and the therapeutic efficacy of drugs. Cytochrome P450 System Part I reviews the structure, function, and mechanism of CYP450 enzymes in facilitating metabolism and drug interactions; we highlight the most important isoforms involved in drug interactions.