Cytochrome P450 System Part I: Background, Mechanism of Interactions, and Main CYP Isoforms Involved in Drug Metabolism

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  Credits  1

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Format

As rates of polypharmacy rise and medication regimens become more complex, the risk of potential CYP-mediated drug-drug interactions is continuously growing. Additionally, the understanding of polymorphism and epigenetics is providing insight into how changes in CYP genes may be responsible for inter-individual variations in these interactions, disease susceptibility, and the therapeutic efficacy of drugs. Cytochrome P450 System Part I reviews the structure, function, and mechanism of CYP450 enzymes in facilitating metabolism and drug interactions; we highlight the most important isoforms involved in drug interactions.

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Course Information

Target Audience

Pharmacist

Author
Fatima Khaja
CDE, PharmD. Ph.D.
Knowledge Level

Specialized Topic

Due to the more narrow range of information, this activity may apply to fewer areas/settings than the gereral topics. It may include updates to guidelines and practice recommendations or address less common disease states or therapies.

Learning Objectives

Pharmacist

Pharmacist

  • Recall CYP enzymes commonly involved in drug interactions and their function, distribution, and nomenclature
  • Compare and contrast the different methods of Drug-drug interactions and those mediated by the CYP system
  • Distinguish CYP2D6 & CYP3A4 from other CYPs in metabolizing drugs and xenobiotics, variability in the population, their substrates, potent inhibitors, and inducers

Course Accreditation

  • Activity Type:
    Knowledge
  • CE Broker
    20-995192
  • Universal Activity Number:
    Pharmacist : 0798-0000-23-072-H01-P
PharmCon is accredited by the Accreditation Council for Pharmacy Education as a provider of continuing pharmacy education.

PharmCon, Inc. is an approved course provider for continuing education for nurses by the Florida Board of Nursing. PharmCon is also recognized by the California Board of Nursing as a provider of nursing programs.

In order to obtain a Statement of Credit, attendees must answer poll questions where presented and complete a program evaluation. Attendees may immediately print their Statement of Credit or leave them stored on the website.

Technology Requirements

  • Hardware Requirements
    Standard Windows/Mac System
    iPad or iPhone
    Minimum screen resolution: 1024x768
    Speakers or headphones
  • Software Requirements
    Standard Windows/Mac System
    iPad or iPhone
    Minimum screen resolution: 1024x768
    Speakers or headphones
  • Network Requirements
    Broadband Internet Connection:
    T1, Hi-speed DSL or Cable
    4G cellular connection
Computer sharing is NOT permitted due to accreditation guidelines on activity monitoring. Credit is earned by one user per device.