Fluoroquinolones Warnings & Side Effects – What You Need to Know- Pharmacy Technician
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Fluoroquinolones are broad-spectrum antibiotics that have
been used to treat infections of varying types and severity since
the 1980s. They are well-tolerated by most patients; however, a
growing body of evidence has linked fluoroquinolone use to rare
but disabling, and potentially permanent, side effects involving
tendons, peripheral nerves, and the central nervous system
(CNS). Cardiac, gastrointestinal (GI), metabolic (glucose), and
ocular side effects, as well as allergic reactions, have also been
reported. In May 2016, the FDA determined that the risks of
fluoroquinolone use for certain uncomplicated infections are
generally greater than the benefits when other treatment options
are available.
Subsequently, the labels of all systemic (oral and
injectable) fluoroquinolones were updated with strengthened
warnings, including a revised boxed warning. The revisions
include "limitation of use" statements advising that, in the treatment
of acute bacterial sinusitis, acute bacterial exacerbation of
chronic bronchitis, and uncomplicated urinary tract infections
(UTIs), fluoroquinolones should be reserved for patients who
have no other options.
This issue reviews uncommon but serious side effects of systemic
fluoroquinolones. Dosing considerations, use in children
and during pregnancy, and potential drug interactions are also
discussed...
